Mass spectrometer

Description

DTU requires a mass spectrometer (MS) with ion mobility and capable of mass spectrometry imaging (MSI), as well as electrospray ionisation (ESI). The MS that is required must be capable of acquiring MSI data at a very small spatial resolution as the primary application of the MS will be in the detection of secondary metabolites produced by microorganisms. The MS needs to have a relatively high mass resolution that is independent of acquisition rate, as the primary application for the MS will be in the detection of secondary metabolites in chemically complex samples with the purpose of undertaking non-targeted multivariate metabolomics studies. The predominant application of the MS will be in non-targeted metabolomics (either in MSI, or ESI), and therefore the required MS must produce high-quality data in data independent acquisition with high sensitivity, at the same time maximising molecular feature information quality. See more in the document ‘Instructions to tenderers’. The DTU Department of Bioengineering requires a mass spectrometer (MS) with ion mobility and capable of mass spectrometry imaging (MSI), as well as electrospray ionisation (ESI). The MS that is required must be capable of acquiring MSI data at a very small spatial resolution as the primary application of the MS will be in the detection of secondary metabolites produced by microorganisms. The MS needs to have a relatively high mass resolution that is independent of acquisition rate, as the primary application for the MS will be in the detection of secondary metabolites in chemically complex samples with the purpose of undertaking non-targeted multivariate metabolomics studies. The predominant application of the MS will be in non-targeted metabolomics (either in MSI, or ESI), and therefore the required MS must produce high-quality data in data independent acquisition with high sensitivity, at the same time maximising molecular feature information quality. Required molecular feature information in data independent acquisition includes collisional cross section (CCS) values for precursor ions, fragmentation spectra, and accurate mass of precursor and product ions. The MS will become part of a metabolomics platform within the Bioengineering Department at the Technical University of Denmark, and therefore, the MS will have a wide variety of users, and data acquired from this MS will be used in teaching settings. To this effect, the required MS must be user friendly, and must be accompanied by a reasonable solution to providing multiple students, short term access to data analysis software.