Biomedical equipment

Description

VMIC requires the ability to rapidly develop and optimise upstream processes using a state-of-the-art Quality by Design (QBD) approach to ensure robustness as well as rapid development. The ability to execute a Design of Experiments (DoE) approach is integral to the assurance of robustness and furthermore ensures that the processes developed are well away from the edge of failure. VMIC will be a centre of excellence for vaccine development in the UK, and must also have the capability to respond rapidly to pandemic situations, therefore it requires a solution that will allow rapid development of robust processes for clients whilst also allowing a significant reduction in operator-hours and time to create credible processes for anti-pandemic vaccine candidates. VMIC requires the ability to rapidly develop and optimise upstream processes using a state-of-the-art Quality by Design (QBD) approach to ensure robustness as well as rapid development. The ability to execute a Design of Experiments (DoE) approach is integral to the assurance of robustness and furthermore ensures that the processes developed are well away from the edge of failure. VMIC will be a centre of excellence for vaccine development in the UK, and must also have the capability to respond rapidly to pandemic situations, therefore it requires a solution that will allow rapid development of robust processes for clients whilst also allowing a significant reduction in operator-hours and time to create credible processes for anti-pandemic vaccine candidates. The Sartorius Ambr250 HT system, including installation and 1 year comprehensive service, allows the simultaneous operation of multiple bioreactor vessels working under different operating parameters, with each parameter, addition, feed etc. controlled by robotics in response to a pre-defined operational plan. The time saved using such an automated system is significant and allows for the rapid development of processes in a fraction of the time required using a more traditional approach. It also allows for the scale-down validation of existing processing parameters, thus speeding up the robustness testing and subsequent validation of existing process parameters.