POLARIS TRIAL
Published
Description
The POLARiS trial will investigate the clinical and cost benefit of two treatments for patients with major LARS who have previously undergone standard non-surgical treatment without improvement. 14,000 cases of rectal cancer are diagnosed in the UK per year. The treatment for advanced rectal cancer is often radiotherapy+/-chemotherapy treatment followed by surgery. This provides good outcomes, with the cancer returning in less than 10% of people. However, the surgery can cause significant long-lasting problems, including problems with bowel, sexual and urinary function. Low anterior resection syndrome (LARS) is a collection of symptoms that people who have undergone a partial or total removal of the rectum may experience, including bowel incontinence or leakage, frequency or urgency of stools, loose stools and incomplete bowel emptying. These symptoms can have a considerable negative impact on patient quality of life and daily functioning. As a result, there is a need to focus efforts on survivorship. LARS symptoms are present in 75% of the patients up to 12 months after surgery and remain in up to 50% of patients for more than 10 years with a major impact on quality of life. There is little evidence to support treatment options for patients with LARS. Despite more acceptance of LARS amongst clinicians, with increased subspecialisation of surgeons and poor reporting of LARS, many centres do not have a clear management pathway and/or are unaware of the treatments available. Transanal irrigation (TAI) is a method of managing conditions such as bowel incontinence or constipation. It involves introducing water through the anus to flush faeces (poo) from the bowel. Sacral Neuromodulation (SNM) involves a small battery powered unit being implanted into the lower back. This is connected to electrodes which rest on the nerves in the lower spine. These two treatment options may improve quality of life for patients with LARS, however supportive evidence is currently lacking. The POLARiS trial will investigate the clinical and cost benefit of two treatments for patients with major LARS who have previously undergone standard non-surgical treatment without improvement. Patients who are not randomised to SNM or TAI will be offered optimised medical management. The study will monitor the bowel function and quality of life in patients who have undergone rectal cancer surgery in the hospitals involved within the last 10 years of the trial commencing. Those patients found to have poor bowel function (major LARS) will be randomised to one of the treatment options and followed up for 2 years after randomisation. The results of the study will be presented at conferences raising awareness of effective treatment options to clinicians, as well as through publication in peer reviewed journals. Patient material will be developed as part of the output of POLARiS which will offer self-management strategies and explanation of treatment options for patients with LARS. The findings of the study will be highlighted through social media to patient groups and relevant charities. This will inform patients and the public that LARS is treatable and which treatment options are potentially available.
Timeline
Publish date
a year ago
Award date
a year ago
Buyer information
NHS Wales - Shared Services Partnership
- Email:
- rhodri.poacher@wales.nhs.uk
Explore contracts and tenders relating to NHS Wales - Shared Services Partnership
Go to buyer profileNotice topic
Source
Sell2WalesTo save this opportunity, sign up to Stotles for free.
Save in appTender tracking
Access a feed of government opportunities tailored to you, in one view. Receive email alerts and integrate with your CRM to stay up-to-date.
Proactive prospecting
Get ahead of competitors by reaching out to key decision-makers within buying organisations directly.
360° account briefings
Create in-depth briefings on buyer organisations based on their historical & upcoming procurement activity.
Collaboration tools
Streamline sales workflows with team collaboration and communication features, and integrate with your favourite sales tools.
Explore similar tenders and contracts
Browse open tenders, recent contract awards and upcoming contract expiries that match similar CPV codes.
- Awarded
QQ24061 - Wolverhampton Local Plan Viability Study
Wolverhampton City Council26,820.33 GBPPublished 16 days ago
- Awarded
Transforming Organisations, Partnerships, and Systems
East Of England NHS Collaborative Hub40,000,000 GBPPublished a month ago
- Awarded
DDP00743 - Salt Evaporator and Medium Active Storage (SEMAS) Feasibility Study
Sellafield Ltd815,994 GBPPublished a month ago
- Awarded
2019/S 211-517049 Financial Advisory Services Framework
Hyde Housing Group425,000,000 GBPPublished a month ago
- Awarded
Sutton Road Flyover Feasibility Study, Direct award Lot 1a
Kingston upon Hull City CouncilPublished 2 months ago
- Awarded
Sutton Road Flyover Feasibility Study, Direct award Lot 1a
Kingston upon Hull City Council37,920 GBPPublished 2 months ago
Explore other contracts published by NHS Wales - Shared Services Partnership
Explore more open tenders, recent contract awards and upcoming contract expiries published by NHS Wales - Shared Services Partnership.
- Awarded
Antibody Quantitation System for the Welsh Blood Services
NHS Wales - Shared Services Partnership267,296 GBPPublished 11 days ago
- Awarded
All Wales Womens Health Obs & Gynae Consumables
NHS Wales - Shared Services Partnership109,489 GBPPublished 11 days ago
- Awarded
EMRTS Nugensis Bespoke Electronic Patient Record System
NHS Wales - Shared Services Partnership168,125 GBPPublished 11 days ago
- Awarded
Antibody Quantitation System for the Welsh Blood Services
NHS Wales - Shared Services Partnership267,296 GBPPublished 11 days ago
- Awarded
Provision of Employee Assistance Programme
NHS Wales - Shared Services Partnership93,600 GBPPublished 12 days ago
- Awarded
Provision of Employee Assistance Programme
NHS Wales - Shared Services Partnership93,600 GBPPublished 12 days ago
- Awarded
Framework Agreement for Healthcare Planning Services for NHS Wales
NHS Wales - Shared Services Partnership6,000,000 GBPPublished 13 days ago
- Awarded
Framework Agreement for Healthcare Planning Services for NHS Wales
NHS Wales - Shared Services Partnership6,000,000 GBPPublished 13 days ago
- Awarded
Provision of Specialist Validation Consultancy Services
NHS Wales - Shared Services Partnership138,320 GBPPublished 16 days ago
Explore more suppliers to NHS Wales - Shared Services Partnership
Sign upExplore top buyers for public sector contracts
Discover open tenders, contract awards and upcoming contract expiries of thousands of public sector buyers below. Gain insights into their procurement activity, historical purchasing trends and more.
- Harrogate Borough Council
- Citizen Housing Group Ltd
- Cork County Council
- Cork Institute of Technology
- Central Statistics Office
- National Infrastructure Commission
- Royal Liverpool and Broadgreen University NHS Trusts
- Public Appointments Service
- HM Government of Gibraltar
- Marine Power Systems Ltd
- St Peter’s Catholic High School
- St Crispin's Infant Primary School
- Gnosall Parish Council
Explore top sources for public sector contracts
Stotles aggregates public sector contract data from every major procurement data source. We ingest this data and surface the most relevant insights for our users. Explore our list of public sector procurement data sources below.